Oxycodone Interactions
There are 615 drugs known to interact with oxycodone, along with 16 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 214 are major, 398 are moderate, and 3 are minor.
- View all 615 medications that may interact with oxycodone
- View oxycodone alcohol/food interactions (1)
- View oxycodone disease interactions (16)
Most frequently checked interactions
View interaction reports for oxycodone and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Celebrex (celecoxib)
- Colace (docusate)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fentanyl Transdermal System (fentanyl)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Lasix (furosemide)
- Lexapro (escitalopram)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Morphine Sulfate ER (morphine)
- Nexium (esomeprazole)
- Protonix (pantoprazole)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Valium (diazepam)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Oxycodone alcohol/food interactions
There is 1 alcohol/food interaction with oxycodone.
Oxycodone disease interactions
There are 16 disease interactions with oxycodone which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
Report options
More about oxycodone
- oxycodone consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (1,143)
- Drug images
- Latest FDA alerts (3)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: Opioids (narcotic analgesics)
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Hydroxyzine
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Cyclobenzaprine
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
